Stimulants Drug Information


Stimulants are psychoactive drugs that induce temporary improvements in mental and/or physical function. The effects of stimulants include enhanced alertness, wakefulness, endurance, productivity and motivation; increased arousal, locomotion, heart rate/blood pressure, and a perception of a diminished requirement for sleep. Symptoms of excessive stimulation of the central nervous system (CNS) include restlessness, difficulty sleeping, tremor, headaches and even psychotic episodes. Loss of appetite (anorexia) and weight loss also occur with CNS stimulants.

Most stimulants are classified as Controlled Substances (CS) in the United States. Designer drugs like MDMA (ecstasy), which have no medical use, are classified as Schedule I CS; the others belong to Schedule II - IV substances. There are several categories of stimulants possessing different chemical structures and employing different pharmacological mechanisms:


Most stimulants are excreted in urine unchanged with only minor metabolites. Numerous precursor drugs metabolize extensively into active amphetamine and methamphetamine.


Stimulants may cause extreme psychological dependence. As drugs of abuse, stimulants are frequently taken to produce a sense of exhilaration, enhance self-esteem, improve mental performance, increase activity, and produce prolonged wakefulness. Stimulants are also popular as appetite suppressants. The ability to improve short-term physical performance made stimulants one of the most abused drug classes in sports.

Methods of Analysis

Immunoassay screens with gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS) for confirmation is a classic approach for amphetamines and cocaine analysis in urine. RTL's comprehensive stimulant test for athletic doping control employs gas chromatography-mass spectrometry (GC-MS).

To learn more about RTL's laboratory drug tests call:


RTL also offers on-site test devices. Click here to view the complete line of Reditest® screening devices.

Drug information data is not definitive and should be used for reference guidelines only.

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